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Article

Presenilin/γ-secretase and α-secretase-like peptidases cleave human MHC Class I proteins

11 Dec 2006

Abstract excerpt

HLA (human leucocyte antigen)-A2 is an MHC Class I protein with primary functions in T-cell development and initi-ation of immune cell responses. MHC I proteins also play roles in intercellular adhesion, apoptosis, cell proliferation and neuronal plasticity. By utilizing a sequence comparison analysis, we recently identified HLA-A2 as a potential substrate for the Alzheimer's disease-associated PS1 (presenilin...

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PMID: 17150042
DOI: 10.1042/bj20060847

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