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<i>HLA-DQA2</i> and <i>HLA-DQB2</i> Genes Are Specifically Expressed in Human Langerhans Cells and Encode a New HLA Class II Molecule

10 Mar 2012

Abstract excerpt

The precise role of human epidermal Langerhans cells (LCs) in immune response is highly controversial. While studying the gene expression profile of these cells, we were intrigued to identify the HLA-DQB2 gene as potentially expressed in LCs. Despite a strong evolutionary conservation of their sequences, the concomitant expression of the poorly polymorphic HLA-DQA2/HLA-DQB2 genes, paralogous to the...

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PMID: 22407913
DOI: 10.4049/jimmunol.1103048

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