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Combinatorial Expression of <i>α</i>- and γ-Protocadherins Alters Their Presenilin-Dependent Processing

3 Apr 2007

Abstract excerpt

Alpha- and gamma-protocadherins (Pcdhs) are type I transmembrane receptors expressed predominantly in the central nervous system and located in part in synapses. They are transcribed from complex genomic loci, giving rise in the mouse to 14 alpha-Pcdh and 22 gamma-Pcdh isoforms consisting of variable domains, each encompassing the extracellular region, the transmembrane region, and part of the intracellular...

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PMID: 17403907
DOI: 10.1128/mcb.01708-06

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