Article
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
The Journal of biological chemistry - 5 Nov 2004
Hasegawa Hiroshi, Sanjo Nobuo, Chen Fusheng, Gu Yong-Jun, Shier Cortney, Petit Agnes, Kawarai Toshitaka, Katayama Taiichi, Schmidt Stephen D, Mathews Paul M, Schmitt-Ulms Gerold, Fraser Paul E, St George-Hyslop Peter
Abstract excerpt
Presenilin 1 or presenilin 2, nicastrin, APH-1, and PEN-2 form high molecular weight complexes that play a pivotal role in the cleavage of various Type I transmembrane proteins, including the beta-amyloid precursor protein. The specific function of PEN-2 is unclear. To explore its function and intermolecular interactions, we conducted deletion and mutagenesis studies on a series of conserved residues at the C...
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