Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.

Molecular and cellular biology - 1 Jul 2006

Bech-Serra Joan J, Santiago-Josefat Belén, Esselens Cary, Saftig Paul, Baselga José, Arribas Joaquín, Canals Francesc

Abstract excerpt

In contrast with the early view of metalloproteases as simple extracellular matrix-degrading entities, recent findings show that they are highly specific modulators of different signaling pathways involved, positively or negatively, in tumor development. Thus, before considering a given metalloprotease a therapeutic target, it seems advisable to characterize its function by identifying its repertoire of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to ADAM17 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Amyloid Precursor Protein Secretases

Share to Aspartic Acid Endopeptidases

Share to Desmoglein 2

Share to Electrophoresis, Gel, Two-Dimensional

Share to Endopeptidases

Share to Epidermal Growth Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 16782893
DOI: 10.1128/MCB.02380-05
PMCID: PMC1489169

Genes

ADAM17
ADAM10
ALCAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Proteomic identification of desmoglein 2 and activated leukocyte cell adhesion molecule as substrates of ADAM17 and ADAM10 by difference gel electrophoresis.PMID 16782893Read ↗

ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistanceSemantic proximity Read ↗

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growthSemantic proximity Read ↗

The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?Semantic proximity Read ↗

ADAM9 as a Potential Target Molecule in CancerSemantic proximity Read ↗

Molecular switch in human diseases-disintegrin and metalloproteinases, ADAM17Semantic proximity Read ↗

ADAM10: Function insights, disease implications, and promise of therapeutic targetingSemantic proximity Read ↗

An Overview of ADAM9: Structure, Activation, and Regulation in Human DiseasesSemantic proximity Read ↗

Distinct roles for ADAM10 and ADAM17 in ectodomain shedding of six EGFR ligands.Semantic proximity Read ↗

ADAM protein family – its role in tumorigenesis, mechanisms of chemoresistance and potential as diagnostic and prognostic factorsSemantic proximity Read ↗

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasisSemantic proximity Read ↗

ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancersSemantic proximity Read ↗

ADAMs and ADAMTSs in cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.