HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.

doi:10.1126/science.1546329

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Article

HLA-A2.1-associated peptides from a mutant cell line: a second pathway of antigen presentation.

Science (New York, N.Y.) - 6 Mar 1992

Henderson R A, Michel H, Sakaguchi K, Shabanowitz J, Appella E, Hunt D F, Engelhard V H

Abstract excerpt

Peptides extracted from HLA-A2.1 class I major histocompatibility complex (MHC) molecules expressed on the antigen processing mutant CEMx721.174.T2 were characterized by electrospray ionization-tandem mass spectrometry. Only seven dominant peptides were found, in contrast to over 200 associated w...

Topics

Amino Acid Sequence
Antigen-Presenting Cells
Antigens
Cell Line
Chromatography, High Pressure Liquid
HLA-A2 Antigen
Humans
Mass Spectrometry
Molecular Sequence Data
Mutation
Peptides
Protein Sorting Signals
T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 1546329
DOI: 10.1126/science.1546329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1546329-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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