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Article

Tumor necrosis factor-alpha-elicited stimulation of gamma-secretase is mediated by c-Jun N-terminal kinase-dependent phosphorylation of presenilin and nicastrin.

Molecular biology of the cell - 1 Oct 2008

Kuo Lan-Hsin, Hu Ming-Kuan, Hsu Wen-Ming, Tung Ying-Tsen, Wang Bo-Jeng, Tsai Wang-Wei, Yen Chen-Tung, Liao Yung-Feng

Abstract excerpt

Gamma-secretase is a multiprotein complex composed of presenilin (PS), nicastrin (NCT), Aph-1, and Pen-2, and it catalyzes the final proteolytic step in the processing of amyloid precursor protein to generate amyloid-beta. Our previous results showed that tumor necrosis factor-alpha (TNF-alpha) can potently stimulate gamma-secretase activity through a c-Jun N-terminal kinase (JNK)-dependent pathway. Here, we...

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Identifiers

PMID: 18667537
DOI: 10.1091/mbc.e07-09-0987
PMCID: PMC2555961

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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