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Article

Signal peptide peptidase dependent cleavage of type II transmembrane substrates releases intracellular and extracellular signals.

European journal of pharmacology - 1 Jul 2006

Dev Kumlesh K, Chatterjee Sandipan, Osinde Maribel, Stauffer Daniela, Morgan Hannah, Kobialko Monika, Dengler Uwe, Rueeger Heinrich, Martoglio Bruno, Rovelli Giorgio

Abstract excerpt

The intramembrane-cleaving proteases (I-CLiPs) presenilin-1 and -2 (PS1 and PS2), signal peptide peptidase (SPP) and the Site-2 protease (S2P) catalyze critical steps in cell signaling and are implicated in diseases such as Alzheimer's disease, hepatitis C virus (HCV) infection and cholesterol homeostasis. Here we describe the development of a cellular assay based on cleavage of the transmembrane sequence of the...

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Identifiers

PMID: 16697367
DOI: 10.1016/j.ejphar.2006.04.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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