Article
Fhit modulates the DNA damage checkpoint response.
Cancer research - 1 Dec 2006
Ishii Hideshi, Mimori Koshi, Inoue Hiroshi, Inageta Taeko, Ishikawa Kazuhiro, Semba Shuho, Druck Teresa, Trapasso Francesco, Tani Kenzaburo, Vecchione Andrea, Croce Carlo M, Mori Masaki, Huebner Kay
Abstract excerpt
In preneoplastic lesions, the DNA damage checkpoint is induced and loss of heterozygosity at the FRA3B/FHIT common chromosome fragile region precedes or is coincident with activation of the checkpoint response in these early stages. Introduction of exogenous Fhit into cells in vitro led to modulation of expression of checkpoint proteins Hus1 and Chk1 at mid-S checkpoint, a modulation that led to induction of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.