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Article

Chk1 and Chk2 kinases in checkpoint control and cancer.

Cancer cell - 1 May 2003

Bartek Jiri, Lukas Jiri

Abstract excerpt

Accumulation of mutations and chromosomal aberrations is one of the hallmarks of cancer cells. This enhanced genetic instability is fueled by defects in the genome maintenance mechanisms including DNA repair and cell cycle checkpoint pathways. Here, we discuss the emerging roles of the mammalian Chk1 and Chk2 kinases as key signal transducers within the complex network of genome integrity checkpoints, as...

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Identifiers

PMID: 12781359
DOI: 10.1016/s1535-6108(03)00110-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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