Article
The role of the FHIT/FRA3B locus in cancer.
Annual review of genetics - 1 Jan 1998
Huebner K, Garrison P N, Barnes L D, Croce C M
Abstract excerpt
Common fragile sites form gaps at characteristic chromosome bands in metaphases from normal cells after aphidicolin induction. The distribution of common fragile sites parallels the positions of neoplasia-associated chromosomal rearrangements, prompting the proposal that fragility disposes to chr...
Topics
- Acid Anhydride Hydrolases
- Alleles
- Amino Acid Sequence
- Chromosome Fragile Sites
- Chromosome Fragility
- Chromosomes, Human, Pair 3
- Female
- Gene Deletion
- Gene Rearrangement
- Genes, Tumor Suppressor
- Homozygote
- Humans
- Male
- Molecular Sequence Data
- Neoplasm Proteins
- Neoplasms
- Physical Chromosome Mapping
- Proteins