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Article

The role of the FHIT/FRA3B locus in cancer.

Annual review of genetics - 1 Jan 1998

Huebner K, Garrison P N, Barnes L D, Croce C M

Abstract excerpt

Common fragile sites form gaps at characteristic chromosome bands in metaphases from normal cells after aphidicolin induction. The distribution of common fragile sites parallels the positions of neoplasia-associated chromosomal rearrangements, prompting the proposal that fragility disposes to chromosomal rearrangements. Implicit in this hypothesis is that genes at fragile sites are altered by chromosome...

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Source

Identifiers

PMID: 9928473
DOI: 10.1146/annurev.genet.32.1.7

Genes

FHIT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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The role of the FHIT/FRA3B locus in cancer.PMID 9928473Read ↗

Fragile Genes That Are Frequently Altered in Cancer: Players Not Passengers.Semantic proximity Read ↗

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DNA Instability at Chromosomal Fragile Sites in CancerSemantic proximity Read ↗

Do FHIT gene alterations play a role in human solid tumors?Semantic proximity Read ↗

Fragile and unstable chromosomes in cancer: causes and consequences.Semantic proximity Read ↗

Common fragile genes and digestive tract cancers.Semantic proximity Read ↗

Cancer prevention and therapy in a preclinical mouse model: impact of FHIT viruses.Semantic proximity Read ↗

Common Fragile Sites: Genomic Hotspots of DNA Damage and CarcinogenesisSemantic proximity Read ↗

The tumor suppressor Fhit acts as a repressor of β-catenin transcriptional activitySemantic proximity Read ↗

Molecular basis for expression of common and rare fragile sites.Semantic proximity Read ↗

FHIT and FRA3B 3p14.2 allele loss are common in lung cancer and preneoplastic bronchial lesions and are associated with cancer-related FHIT cDNA splicing aberrations.Semantic proximity Read ↗

Allele-specific late replication and fragility of the most active common fragile site, FRA3B.Semantic proximity Read ↗

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