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Article

PI3-kinase/Akt-dependent antiapoptotic signaling by the PDGF alpha receptor is negatively regulated by Src family kinases.

FEBS letters - 22 Dec 2006

Vantler Marius, Huntgeburth Michael, Caglayan Evren, Ten Freyhaus Henrik, Schnabel Petra, Rosenkranz Stephan

Abstract excerpt

Regulation of growth factor dependent cell survival is crucial for development and disease progression. Here, we report a novel function of Src kinases as a negative regulator of platelet-derived growth factor (PDGF) dependent cell survival. We characterized a series of PDGF alpha receptor (PDGFRA) mutants, which lack the binding sites for Src, phosphatidylinositol 3'-kinase (PI3K), SHP-2 or phospholipase...

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Source

Identifiers

PMID: 17141222
DOI: 10.1016/j.febslet.2006.11.034

Genes

PDGFRA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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