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Article

Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.

Cellular signalling - 1 Sept 2010

Wardega Piotr, Heldin Carl-Henrik, Lennartsson Johan

Abstract excerpt

Activation of platelet-derived growth factor (PDGF) receptors occurs through ligand-induced dimerization and autophosphorylation. In this study, we investigated the effects of mutation of tyrosine residue 857 (Y857) in the activation loop of the PDGF beta-receptor (PDGFRbeta) to phenylalanine (Y857F). In agreement with previous observations, we found that PDGFRbeta(Y857F) had a severely diminished in vitro kinase...

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Identifiers

PMID: 20494825
DOI: 10.1016/j.cellsig.2010.05.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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