Article

Ligand-independent Activation of Platelet-derived Growth Factor Receptor β promotes contraction of retinal pigment epithelial cells

2023-01-20

Abstract excerpt

<h4>Background: </h4> Epiretinal membranes in patients with proliferative vitreoretinopathy (PVR) consist of extracellular matrix and a number of cell types including retinal pigment epithelial (RPE) cells and fibroblasts, whose contraction causes retinal detachment. In RPE cells depletion of platelet-derived growth factor (PDGF) receptor (PDGFR)β suppresses vitreous-induced Akt activation, whereas in fibroblasts...

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Literature Corpus work: 8a5df218-96aa-5bba-ae92-8c95f3aeca40
DOI: 10.21203/rs.3.rs-2418444/v1

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