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Article

Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults.

Journal of affective disorders - 1 Jun 2007

Jokela Markus, Räikkönen Katri, Lehtimäki Terho, Rontu Riikka, Keltikangas-Järvinen Liisa

Abstract excerpt

BACKGROUND: Tryptophan hydroxylases (TPHs) are involved in the biosynthesis of serotonin and are therefore candidate genes for psychiatric disorders, including depression. We examined whether the common 218 A > C and 779 A > C polymorphisms in the tryptophan hydroxylase 1 gene (TPH1) moderated the association between perceived social support and sub-clinical depressive symptoms in adults. METHODS: The subjects...

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Source

Identifiers

PMID: 17134762
DOI: 10.1016/j.jad.2006.10.016

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Tryptophan hydroxylase 1 gene (TPH1) moderates the influence of social support on depressive symptoms in adults.PMID 17134762Read ↗

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