TPH2-703 G/T polymorphism is associated with stress, depression, and psychosocial symptoms in mentally healthy Mexicans.

doi:10.1016/j.brainres.2023.148479

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Article

TPH2-703 G/T polymorphism is associated with stress, depression, and psychosocial symptoms in mentally healthy Mexicans.

Brain research - 15 Oct 2023

Hernandez-Mixteco Margarita, Bernal-Morales Blandina, Valenzuela Olga Lidia, Rodríguez-Landa Juan Francisco, Cerna-Cortes Jorge Francisco, García-Montalvo Eliud Alfredo

Abstract excerpt

Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of serotonin synthesis. TPH2 is the brain-specific isoform of this enzyme, and genetic variations in the TPH2 gene have been shown to impact its transcription and enzymatic activity and are associated with mood disorders. In this study we focused on the rs4570625 (-703G/T) single nucleotide polymorphism of TPH2 gene. By using conventional polymerase...

Topics

Male
Depression
Genetic Predisposition to Disease
Tryptophan Hydroxylase
Humans
Quality of Life
Stress, Psychological
Genotype
Polymorphism, Single Nucleotide
Psychosocial Functioning
North American People

Source

Open in PubMed

Identifiers

PMID: 37423455
DOI: 10.1016/j.brainres.2023.148479

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