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Article

Tryptophan hydroxylase 2 gene and alcohol use among college students.

Addiction biology - 1 Sept 2008

Gacek Paul, Conner Tamlin S, Tennen Howard, Kranzler Henry R, Covault Jonathan

Abstract excerpt

Genes that regulate serotonin activity are regarded as promising predictors of heavy alcohol use. Tryptophan hydroxylase (TPH2) plays an important role in serotonergic neurotransmission by serving as the rate-limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. Despite the link between TPH2 and serotonergic function, TPH2's role in the pathogenesis of alcohol-use disorders remains...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18782386
DOI: 10.1111/j.1369-1600.2008.00118.x
PMCID: PMC2695976

Genes

TPH2
TPH1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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