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Article

Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression.

Journal of affective disorders - 1 Jul 2008

Porter Richard J, Mulder Roger T, Joyce Peter R, Miller Allison L, Kennedy Martin

Abstract excerpt

BACKGROUND: Genetic variants have been discovered in two genes encoding for tryptophan hydroxylase (TPH)-TPH1 and TPH2. Low tryptophan (TRP) levels are associated with depression and may arise because of stress. Evidence suggests that hypothalamic and peripheral 5HT systems have a significant rol...

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Source

Identifiers

PMID: 18177948
DOI: 10.1016/j.jad.2007.11.010

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18177948-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Tryptophan hydroxylase gene (TPH1) and peripheral tryptophan levels in depression.PMID 18177948Read ↗

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TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

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The tryptophan hydroxylase gene influences risk for bipolar disorder but not major depressive disorder: results of meta-analyses.Semantic proximity Read ↗

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