Article
Genetic analyses of thiopurine methyltransferase polymorphisms in Greenlandic and Danish populations.
Acta paediatrica (Oslo, Norway : 1992) - 1 Dec 2006
Toft Nina, Nygaard Ulrikka, Gregers Jannie, Schmiegelow Kjeld
Abstract excerpt
AIM: To determine the frequency of thiopurine methyltransferase (TPMT) low-activity alleles in the Greenlandic and Danish populations. METHODS: 142 Greenlandic individuals and 200 Danish blood donors were screened for the TPMT G460A and A719G low-activity alleles. RESULTS: Thiopurine methyltransferase low-activity alleles were significantly higher in the Greenlandic compared to the Danish population, being 8.1%...
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