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Article

The frequency and distribution of thiopurine methyltransferase alleles in Caucasian and Asian populations.

Pharmacogenetics - 1 Feb 1999

Collie-Duguid E S, Pritchard S C, Powrie R H, Sludden J, Collier D A, Li T, McLeod H L

Abstract excerpt

Thiopurine methyltransferase metabolizes 6-mercaptopurine, thioguanine and azathioprine, thereby regulating cytotoxicity and clinical response to these thiopurine drugs. In healthy Caucasian populations, 89-94% of individuals have high thiopurine methyltransferase activity, 6-11% intermediate and...

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Identifiers

PMID: 10208641
DOI: 10.1097/00008571-199902000-00006

Genes

TPMT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-10208641-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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