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Article

Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.

Clinical chemistry - 1 Feb 2004

Haglund Sofie, Lindqvist Malin, Almer Sven, Peterson Curt, Taipalensuu Jan

Abstract excerpt

BACKGROUND: Interindividual differences in therapeutic efficacy in patients treated with thiopurines might be explained by the presence of thiopurine S-methyltransferase (TPMT) alleles that encode for reduced TPMT enzymatic activity. It is therefore of value to know an individual's inherent capac...

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Source

Identifiers

PMID: 14656901
DOI: 10.1373/clinchem.2003.023846

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14656901-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.PMID 14656901Read ↗

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Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function.Semantic proximity Read ↗

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Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23.Semantic proximity Read ↗

Identification of rare defective allelic variants in cases of thiopurine S-methyltransferase deficient activity.Semantic proximity Read ↗

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