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Article

Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.

Clinical chemistry - 1 Feb 2004

Haglund Sofie, Lindqvist Malin, Almer Sven, Peterson Curt, Taipalensuu Jan

Abstract excerpt

BACKGROUND: Interindividual differences in therapeutic efficacy in patients treated with thiopurines might be explained by the presence of thiopurine S-methyltransferase (TPMT) alleles that encode for reduced TPMT enzymatic activity. It is therefore of value to know an individual's inherent capacity to express TPMT. METHOD: We developed a pyrosequencing method to detect 10 single-nucleotide polymorphisms (SNPs)...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 14656901
DOI: 10.1373/clinchem.2003.023846

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.PMID 14656901Read ↗

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.Semantic proximity Read ↗

Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function.Semantic proximity Read ↗

Polymorphisms of the TPMT gene in the Czech healthy population and patients with inflammatory bowel disease.Semantic proximity Read ↗

AN EPIDEMIOLOGICAL STUDY OF THIOPURINE-METHYLTRANSFERASE VARIANTS IN A CROATIAN INFLAMMATORY BOWEL DISEASE PATIENT COHORT.Semantic proximity Read ↗

Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23.Semantic proximity Read ↗

Identification of rare defective allelic variants in cases of thiopurine S-methyltransferase deficient activity.Semantic proximity Read ↗

Genetic Polymorphism of Thiopurine S-Methyltransferase: Molecular Mechanisms and Clinical ImportanceSemantic proximity Read ↗

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Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.Semantic proximity Read ↗

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Genotyping of thiopurine methyltransferase using pyrosequencing.Semantic proximity Read ↗

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