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Article

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.

Clinical pharmacology and therapeutics - 1 Jul 1997

Otterness D, Szumlanski C, Lennard L, Klemetsdal B, Aarbakke J, Park-Hah J O, Iven H, Schmiegelow K, Branum E, O'Brien J, Weinshilboum R

Abstract excerpt

Thiopurine methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT activity is regulated by a common genetic polymorphism that is associated with large individual variations in thiopurine toxicity and efficacy. We previously cloned the functional gene for human TPMT and reported a common variant allele for low enzyme activity, TPMT*3A, that contains point mutations at cDNA nucleotides 460...

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Identifiers

PMID: 9246020
DOI: 10.1016/S0009-9236(97)90152-1

Genes

TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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