Thiopurine methyltransferase alleles in British and Ghanaian populations.

doi:10.1093/hmg/8.2.367

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Article

Thiopurine methyltransferase alleles in British and Ghanaian populations.

Human molecular genetics - 1 Feb 1999

Ameyaw M M, Collie-Duguid E S, Powrie R H, Ofori-Adjei D, McLeod H L

Abstract excerpt

Thiopurine methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs such as 6-mercapto-purine, 6-thioguanine and azathioprine. TPMT activity is inherited as an autosomal co-dominant trait, and several mutations in the TPMT gene have been identified which correlate with a low activ...

Topics

Adult
Alleles
Black People
DNA
Female
Gene Frequency
Genotype
Ghana
Heterozygote
Homozygote
Humans
Male
Methyltransferases
Mutation
Polymorphism, Restriction Fragment Length
Scotland
White People

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