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Article

Phenotypic and genotypic analysis of thiopurine s-methyltransferase polymorphism in the bulgarian population.

Therapeutic drug monitoring - 1 Oct 2003

Indjova Dessislava, Atanasova Srebrena, Shipkova Maria, Armstrong Victor W, Oellerich Michael, Svinarov Dobrin

Abstract excerpt

Genetic polymorphism of TPMT activity is an important factor responsible for large individual differences in thiopurine toxicity and therapeutic efficacy. The aim of this study was to determine the distribution of TPMT activity as well as the types and frequencies of mutant alleles in a Bulgarian population sample. TPMT activity was measured in 313 Bulgarians, using an established HPLC procedure. All individuals...

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Source

Identifiers

PMID: 14508387
DOI: 10.1097/00007691-200310000-00013

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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