Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.

Pharmacogenetics - 1 Apr 2004

Lindqvist Malin, Haglund Sofie, Almer Sven, Peterson Curt, Taipalensu Jan, Hertervig Erik, Lyrenäs Ebbe, Söderkvist Peter

Abstract excerpt

The polymorphic enzyme thiopurine methyltransferase (TPMT) is involved in the methylation of thiopurines. On comparing the phenotype with the genotype in Swedish patients with inflammatory bowel disease and healthy individuals, we found two discordant cases with low TPMT enzyme activity (0.3 and...

Read the complete abstract on PubMed

Topics

Base Sequence
Case-Control Studies
DNA Primers
Female
Genotype
Humans
Inflammatory Bowel Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Methylation

Methyltransferases

Phenotype

Source

Identifiers

PMID: 15083071
DOI: 10.1097/00008571-200404000-00006

Genes

TPMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15083071-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity.PMID 15083071Read ↗

Pyrosequencing of TPMT alleles in a general Swedish population and in patients with inflammatory bowel disease.Semantic proximity Read ↗

Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene.Semantic proximity Read ↗

Explaining TPMT genotype/phenotype discrepancy by haplotyping of TPMT*3A and identification of a novel sequence variant, TPMT*23.Semantic proximity Read ↗

Identification of rare defective allelic variants in cases of thiopurine S-methyltransferase deficient activity.Semantic proximity Read ↗

Human thiopurine methyltransferase pharmacogenetics: gene sequence polymorphisms.Semantic proximity Read ↗

Genotyping of thiopurine methyltransferase using pyrosequencing.Semantic proximity Read ↗

Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function.Semantic proximity Read ↗

Identification of a novel thiopurine S-methyltransferase allele (TPMT*37).Semantic proximity Read ↗

Characterisation of novel defective thiopurine S-methyltransferase allelic variants.Semantic proximity Read ↗

Genetic polymorphism of thiopurine S-methyltransferase: clinical importance and molecular mechanisms.Semantic proximity Read ↗

AN EPIDEMIOLOGICAL STUDY OF THIOPURINE-METHYLTRANSFERASE VARIANTS IN A CROATIAN INFLAMMATORY BOWEL DISEASE PATIENT COHORT.Semantic proximity Read ↗

Detection of a novel single nucleotide polymorphism of the human thiopurine s-methyltransferase gene in a Chinese individual.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.