Article
Distinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity.
International journal of molecular sciences - 15 Sept 2020
Thompson Laurie R, Oliveira Thais G, Hermann Evan R, Chowanadisai Winyoo, Clarke Stephen L, Montgomery McKale R
Abstract excerpt
The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer. In addition to loss of tumor suppressor functions, mutations in TP53 promote cancer progression by altering cellular iron acquisition and metabolism. A newly identified role for TP53 in the coordination of iron homeostasis and cancer cell survival lies in the ability for TP53 to protect against ferroptosis, a form of iron-mediated...
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