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Article

Inhibition of IRP2-dependent reprogramming of iron metabolism suppresses tumor growth in colorectal cancer

23 Aug 2024

Abstract excerpt

BACKGROUND: Dysregulation of iron metabolism is implicated in malignant transformation, cancer progression, and therapeutic resistance. Here, we demonstrate that iron regulatory protein 2 (IRP2) preferentially regulates iron metabolism and promotes tumor growth in colorectal cancer (CRC). METHODS: IRP2 knockdown and knockout cells were generated using RNA interference and clustered regularly interspaced short...

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PMID: 39180081
DOI: 10.1186/s12964-024-01769-6

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