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Article

Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells.

The Journal of biological chemistry - 12 May 2006

Yoo Min-Hyuk, Xu Xue-Ming, Carlson Bradley A, Gladyshev Vadim N, Hatfield Dolph L

Abstract excerpt

Dietary selenium has potent cancer prevention activity. Both low molecular weight selenocompounds and selenoproteins are implicated in this effect. Thioredoxin reductase 1 (TR1) is one of the major antioxidant and redox regulators in mammals that supports p53 function and other tumor suppressor activities. However, this selenium-containing oxidoreductase is also overexpressed in many malignant cells and has been...

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Identifiers

PMID: 16565519
DOI: 10.1074/jbc.C600012200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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