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Article

Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression

10 Apr 2020

Abstract excerpt

Abstract Iron regulatory protein 2 (IRP2) is a key regulator of iron homeostasis and is found to be altered in several types of human cancer. However, how IRP2 contributes to tumorigenesis remains to be elucidated. In this study, we sought to investigate the role of IRP2 in tumorigenesis and found that IRP2 promotes cell growth by repressing TAp63, a member of p53 tumor suppressor family. Specifically, we found...

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PMID: 32276991
DOI: 10.1158/1541-7786.mcr-19-1104

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