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Article

Do cancer cells selectively mutate HFE to increase their intracellular iron?

Oncology reports - 1 Aug 2005

Müller Claudia I, Miller Carl W, Kawabata Hiroshi, McKenna Robert J, Marchevsky Alberto M, Koeffler H Phillip

Abstract excerpt

Malignant cells compared to their normal counter-parts, have an increased requirement for iron in order to achieve an enhanced cell growth. Transferrin receptor (TfR), an essential transport protein that enables cells to satisfy their need of iron, is upregulated in cancer cells. The hemochromatosis gene (HFE) produces a protein that interacts with TfR; and we hypothesized that tumor cells would selectively...

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Source

Identifiers

PMID: 16012706

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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