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Article

Homolactate fermentation by metabolically engineered Escherichia coli strains.

Applied and environmental microbiology - 1 Jan 2007

Zhu Y, Eiteman M A, DeWitt K, Altman E

Abstract excerpt

We report the homofermentative production of lactate in Escherichia coli strains containing mutations in the aceEF, pfl, poxB, and pps genes, which encode the pyruvate dehydrogenase complex, pyruvate formate lyase, pyruvate oxidase, and phosphoenolpyruvate synthase, respectively. The process uses a defined medium and two distinct fermentation phases: aerobic growth to an optical density of about 30, followed by...

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Identifiers

PMID: 17122396
DOI: 10.1128/AEM.02022-06
PMCID: PMC1796981

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Source receipt: pubmed, retrieved 7 Sept 2026.

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