Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High glycolytic flux improves pyruvate production by a metabolically engineered Escherichia coli strain.

Applied and environmental microbiology - 1 Nov 2008

Zhu Yihui, Eiteman Mark A, Altman Ronni, Altman Elliot

Abstract excerpt

We report pyruvate formation in Escherichia coli strain ALS929 containing mutations in the aceEF, pfl, poxB, pps, and ldhA genes which encode, respectively, the pyruvate dehydrogenase complex, pyruvate formate lyase, pyruvate oxidase, phosphoenolpyruvate synthase, and lactate dehydrogenase. The glycolytic rate and pyruvate productivity were compared using glucose-, acetate-, nitrogen-, or phosphorus-limited...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetic Acid
Share to Enzymes
Share to Glucose

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Glycolysis

Share to Metabolic Networks and Pathways

Share to Nitrogen

Share to Phosphorus

Share to Pyruvic Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 18806005
DOI: 10.1128/AEM.01610-08
PMCID: PMC2576684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High glycolytic flux improves pyruvate production by a metabolically engineered Escherichia coli strain.PMID 18806005Read ↗

Pyruvate Production by Escherichia coli by Use of Pyruvate Dehydrogenase Variants.Semantic proximity Read ↗

Homolactate fermentation by metabolically engineered Escherichia coli strains.Semantic proximity Read ↗

The effect of acetate pathway mutations on the production of pyruvate in Escherichia coli.Semantic proximity Read ↗

Engineering the metabolism of Escherichia coli W3110 for the conversion of sugar to redox-neutral and oxidized products: homoacetate production.Semantic proximity Read ↗

Pyruvate oxidase contributes to the aerobic growth efficiency of Escherichia coli.Semantic proximity Read ↗

Enhancement of lactate and succinate formation in adhE or pta-ackA mutants of NADH dehydrogenase-deficient Escherichia coli.Semantic proximity Read ↗

Coordinated activation of PTA-ACS and TCA cycles strongly reduces overflow metabolism of acetate in Escherichia coli.Semantic proximity Read ↗

Identification of Enzymatic Bottlenecks for the Aerobic Production of Malate from Glycerol by the Systematic Gene Overexpression of Anaplerotic Enzymes in Escherichia coli.Semantic proximity Read ↗

Comparison of different strategies to reduce acetate formation in Escherichia coli.Semantic proximity Read ↗

Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli.Semantic proximity Read ↗

Metabolic evolution of energy-conserving pathways for succinate production in Escherichia coli.Semantic proximity Read ↗

Characterization of the acetate-producing pathways in Escherichia coli.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.