Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

High yield production of four-carbon dicarboxylic acids by metabolically engineered Escherichia coli.

Journal of industrial microbiology & biotechnology - 1 Jan 2018

Martinez Irene, Gao Haijun, Bennett George N, San Ka-Yiu

Abstract excerpt

Several metabolic engineered Escherichia coli strains were constructed and evaluated for four-carbon dicarboxylic acid production. Fumarase A, fumarase B and fumarase C single, double and triple mutants were constructed in a ldhA adhE mutant background overexpressing the pyruvate carboxylase from Lactococcus lactis. All the mutants produced succinate as the main four-carbon (C4) dicarboxylic acid product when...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Dehydrogenase
Share to Carbon
Share to Fumarate Hydratase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to L-Lactate Dehydrogenase

Share to Lactococcus lactis

Share to Malates

Share to Metabolic Engineering

Share to Succinic Acid

Source

Identifiers

PMID: 29196893
DOI: 10.1007/s10295-017-1991-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

High yield production of four-carbon dicarboxylic acids by metabolically engineered Escherichia coli.PMID 29196893Read ↗

Metabolic engineering of Escherichia coli and in silico comparing of carboxylation pathways for high succinate productivity under aerobic conditions.Semantic proximity Read ↗

Enhanced succinic acid production under acidic conditions by introduction of glutamate decarboxylase system in E. coli AFP111.Semantic proximity Read ↗

Chemostat culture characterization of Escherichia coli mutant strains metabolically engineered for aerobic succinate production: a study of the modified metabolic network based on metabolite profile, enzyme activity, and gene expression profile.Semantic proximity Read ↗

High-yield anaerobic succinate production by strategically regulating multiple metabolic pathways based on stoichiometric maximum in Escherichia coli.Semantic proximity Read ↗

Escherichia coli genome-scale metabolic gene knockout of lactate dehydrogenase (ldhA), increases succinate production from glycerol.Semantic proximity Read ↗

Identification of Enzymatic Bottlenecks for the Aerobic Production of Malate from Glycerol by the Systematic Gene Overexpression of Anaplerotic Enzymes in Escherichia coli.Semantic proximity Read ↗

Effect of Sorghum vulgare phosphoenolpyruvate carboxylase and Lactococcus lactis pyruvate carboxylase coexpression on succinate production in mutant strains of Escherichia coli.Semantic proximity Read ↗

Production of succinate by a pflB ldhA double mutant of Escherichia coli overexpressing malate dehydrogenase.Semantic proximity Read ↗

Directed pathway evolution of the glyoxylate shunt in Escherichia coli for improved aerobic succinate production from glycerol.Semantic proximity Read ↗

Comparative fluxome and metabolome analysis for overproduction of succinate in Escherichia coli.Semantic proximity Read ↗

Metabolic engineering of Escherichia coli for acetaldehyde overproduction using pyruvate decarboxylase from Zymomonas mobilis.Semantic proximity Read ↗

Model-aided atpE gene knockout strategy in Escherichia coli for enhanced succinic acid production from glycerol.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.