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Article

Pyruvate Production by Escherichia coli by Use of Pyruvate Dehydrogenase Variants.

Applied and environmental microbiology - 11 Jun 2021

Moxley W Chris, Eiteman Mark A

Abstract excerpt

Altering metabolic flux at a key branch point in metabolism has commonly been accomplished through gene knockouts or by modulating gene expression. An alternative approach to direct metabolic flux preferentially toward a product is decreasing the activity of a key enzyme through protein engineering. In Escherichia coli, pyruvate can accumulate from glucose when carbon flux through the pyruvate dehydrogenase...

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Identifiers

PMID: 33863707
DOI: 10.1128/AEM.00487-21
PMCID: PMC8315933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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