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Article

Comparison of different strategies to reduce acetate formation in Escherichia coli.

Biotechnology progress - 1 Jan 2000

De Mey Marjan, Lequeux Gaspard J, Beauprez Joeri J, Maertens Jo, Van Horen Ellen, Soetaert Wim K, Vanrolleghem Peter A, Vandamme Erick J

Abstract excerpt

E. coli cells produce acetate as an extracellular coproduct of aerobic cultures. Acetate is undesirable because it retards growth and inhibits protein formation. Most process designs or genetic modifications to minimize acetate formation aim at balancing growth rate and oxygen consumption. In this research, three genetic approaches to reduce acetate formation were investigated: (1) direct reduction of the carbon...

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PMID: 17715942
DOI: 10.1021/bp070170g

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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