Article
Metabolic engineering of Escherichia coli and in silico comparing of carboxylation pathways for high succinate productivity under aerobic conditions.
Microbiological research - 1 Jan 2000
Yang Jiangang, Wang Zhiwen, Zhu Nianqing, Wang Baiyun, Chen Tao, Zhao Xueming
Abstract excerpt
A novel aerobic succinate production system was strategically designed that allows Escherichia coli to produce and accumulate succinate with high specific productivity under aerobic conditions. Mutations in the tricarboxylic acid cycle (sdhA, iclR) and byproduct formation pathways (poxB, ackA-pta, mgsA) of E. coli were created to construct the glyoxylate cycle and oxidative branch of the TCA cycle for aerobic...
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