Article
Mutually exclusive T-cell receptor induction and differential susceptibility to human immunodeficiency virus type 1 mutational escape associated with a two-amino-acid difference between HLA class I subtypes.
Journal of virology - 1 Feb 2007
Yu Xu G, Lichterfeld Mathias, Chetty Senica, Williams Katie L, Mui Stanley K, Miura Toshiyuki, Frahm Nicole, Feeney Margaret E, Tang Yanhua, Pereyra Florencia, Labute Montiago X, Pfafferott Katja, Leslie Alisdair, Crawford Hayley, Allgaier Rachel, Hildebrand William, Kaslow Richard, Brander Christian, Allen Todd M, Rosenberg Eric S, Kiepiela Photini, Vajpayee Madhu, Goepfert Paul A, Altfeld Marcus, Goulder Philip J R, Walker Bruce D
Abstract excerpt
The relative contributions of HLA alleles and T-cell receptors (TCRs) to the prevention of mutational viral escape are unclear. Here, we examined human immunodeficiency virus type 1 (HIV-1)-specific CD8(+) T-cell responses restricted by two closely related HLA class I alleles, B*5701 and B*5703, that differ by two amino acids but are both associated with a dominant response to the same HIV-1 Gag epitope KF11...
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