Article
Immunodominance and cross-reactivity of B5703-restricted CD8 T lymphocytes from HIV type 1 subtype C-infected Ethiopians.
AIDS research and human retroviruses - 1 Mar 2005
Currier Jeffrey R, Harris Matthew E, Cox Josephine H, McCutchan Francine E, Birx Deborah L, Maayan Shlomo, Ferrari Guido
Abstract excerpt
The HLA-B57 allele family is associated with slow progression to disease in HIV-1-infected individuals and restricts a potent CD8 response against the p24 protein. This study was designed to assess the sequence variation and the CD8 response against B57-restricted epitopes of the p24 protein in a cohort of HIV-1 subtype C-infected individuals possessing a high frequency of the B5703 allele. Gag sequences were...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
