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Article

Despite biased TRBV gene usage against a dominant HLA B57-restricted epitope, TCR diversity can provide recognition of circulating epitope variants.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2008

Simons Brenna C, Vancompernolle Scott E, Smith Rita M, Wei Jie, Barnett Louise, Lorey Shelly L, Meyer-Olson Dirk, Kalams Spyros A

Abstract excerpt

The role of epitope-specific TCR repertoire diversity in the control of HIV-1 viremia is unknown. Further analysis at the clonotype level is important for understanding the structural aspects of the HIV-1 specific repertoire that directly relate to CTL function and ability to suppress viral replication. In this study, we performed in-depth analysis of T cell clonotypes directed against a dominantly recognized HLA...

Read the complete abstract on PubMed

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Share to Antigen Presentation
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to HIV Core Protein p24

Share to HLA-B Antigens

Share to Immunodominant Epitopes

Share to Immunoglobulin Variable Region

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 18802118
DOI: 10.4049/jimmunol.181.7.5137

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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