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Article

Features of Highly Homologous T-Cell Receptor Repertoire in the Immune Response to Mutations in Immunogenic Epitopes.

International journal of molecular sciences - 23 Nov 2024

Zornikova Ksenia, Dianov Dmitry, Ivanova Natalia, Davydova Vassa, Nenasheva Tatiana, Fefelova Ekaterina, Bogolyubova Apollinariya

Abstract excerpt

CD8+ T-cell immunity, mediated through interactions between human leukocyte antigen (HLA) and the T-cell receptor (TCR), plays a pivotal role in conferring immune memory and protection against viral infections. The emergence of SARS-CoV-2 variants presents a significant challenge to the existing population immunity. While numerous SARS-CoV-2 mutations have been associated with immune evasion from CD8+ T cells,...

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Share to CD8-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA-A24 Antigen

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Share to Receptors, Antigen, T-Cell

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Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 39684303
DOI: 10.3390/ijms252312591
PMCID: PMC11641755

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