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Article

Cellular toxicity induced by SRF-mediated transcriptional squelching.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Mar 2007

Lin Huey, McGrath Jami, Wang Ping, Lee Techung

Abstract excerpt

The transcriptional activator serum response factor (SRF) is a member of the immediate early gene family known to promote embryonic development, cell growth, and myogenesis through interaction with multiple nuclear protein factors. Previous studies have shown that SRF possesses potent transcriptional activation domains that can interfere with gene expression at artificially high expression levels through...

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Identifiers

PMID: 17116645
DOI: 10.1093/toxsci/kfl172

Genes

SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cellular toxicity induced by SRF-mediated transcriptional squelching.PMID 17116645Read ↗

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Suppression of Ras transformation by serum response factor.Semantic proximity Read ↗

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The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.Semantic proximity Read ↗

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