Article
RRR-alpha-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA-MB-435 breast cancer cells.
Molecular carcinogenesis - 1 Aug 1998
Yu W, Simmons-Menchaca M, You H, Brown P, Birrer M J, Sanders B G, Kline K
Abstract excerpt
We have demonstrated that RRR-alpha-tocopheryl succinate (10 microg/mL vitamin E succinate (VES) treatment of estrogen receptor-negative MDA-MB-435 human breast cancer cells induces 9, 19, 51, and 72% apoptotic cells on days 1-4, respectively, after treatment, which involves transforming growth f...
Topics
- Apoptosis
- Breast Neoplasms
- Consensus Sequence
- DNA, Neoplasm
- Enzyme Activation
- Gene Expression
- Humans
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 4
- Mitogen-Activated Protein Kinase Kinases
- Mutation
- Oligonucleotides, Antisense
- Phosphorylation