Article
In vitro squelching of activated transcription by serum response factor: evidence for a common coactivator used by multiple transcriptional activators.
Nucleic acids research - 11 Feb 1992
Prywes R, Zhu H
Abstract excerpt
Low amounts of serum response factor (SRF) activate transcription in vitro from a fos promoter construct containing an SRF binding site. Using this human HeLa cell-derived in vitro transcription system, we have found that high amounts of SRF inhibited, or 'squelched', transcription from this cons...
Topics
- Base Sequence
- Cyclic AMP Response Element-Binding Protein
- DNA-Binding Proteins
- Fungal Proteins
- Genes, fos
- HeLa Cells
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Promoter Regions, Genetic
- Serum Response Factor
- Trans-Activators
- Transcription Factors
- Transcription, Genetic