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Article

In vitro squelching of activated transcription by serum response factor: evidence for a common coactivator used by multiple transcriptional activators.

Nucleic acids research - 11 Feb 1992

Prywes R, Zhu H

Abstract excerpt

Low amounts of serum response factor (SRF) activate transcription in vitro from a fos promoter construct containing an SRF binding site. Using this human HeLa cell-derived in vitro transcription system, we have found that high amounts of SRF inhibited, or 'squelched', transcription from this construct. Transcription from several other promoters activated by different gene-specific factors, including CREB and the...

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Identifiers

PMID: 1531519
DOI: 10.1093/nar/20.3.513
PMCID: PMC310416

Genes

SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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In vitro squelching of activated transcription by serum response factor: evidence for a common coactivator used by multiple transcriptional activators.PMID 1531519Read ↗

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