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Article

Heat shock protein 70 binding inhibits the nuclear import of apoptosis-inducing factor.

Oncogene - 2 Oct 2003

Gurbuxani Sandeep, Schmitt Elise, Cande Celine, Parcellier Arnaud, Hammann Arlette, Daugas Eric, Kouranti Ilektra, Spahr Chris, Pance Alena, Kroemer Guido, Garrido Carmen

Abstract excerpt

Heat shock protein 70 (HSP70) can inhibit apoptosis by neutralizing and interacting with apoptosis-inducing factor (AIF), a mitochondrial flavoprotein that translocates upon apoptosis induction to the nucleus, via the cytosol. Here, we show that only members of the HSP70 family interact with AIF. Systematic deletion mapping revealed the existence of three distinct functional regions in the AIF protein: (1) a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14555980
DOI: 10.1038/sj.onc.1206794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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