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Article

Suppression of Ras transformation by serum response factor.

The Journal of biological chemistry - 13 May 1994

Kim J H, Johansen F E, Robertson N, Catino J J, Prywes R, Kumar C C

Abstract excerpt

Serum response factor (SRF) is a nuclear transcription factor that binds to the serum response element (SRE) found in the promoter regions of a number of growth factor-inducible genes, as well as muscle-specific genes. The smooth muscle alpha-actin promoter contains two SRE sequences that can bind to SRF. Its expression is repressed in Ras-transformed fibroblast cells and derepressed in revertant cells. In this...

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Identifiers

PMID: 8188648

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Suppression of Ras transformation by serum response factor.PMID 8188648Read ↗

Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer.Semantic proximity Read ↗

Transformation blocks differentiation-induced inhibition of serum response factor interactions with serum response elements.Semantic proximity Read ↗

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.Semantic proximity Read ↗

Myocardin is a master regulator of smooth muscle gene expression.Semantic proximity Read ↗

Myocardin: a component of a molecular switch for smooth muscle differentiation.Semantic proximity Read ↗

Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.Semantic proximity Read ↗

The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo.Semantic proximity Read ↗

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.Semantic proximity Read ↗

Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression.Semantic proximity Read ↗

Suppression of ras oncogene-mediated transformation.Semantic proximity Read ↗

Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.Semantic proximity Read ↗

Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor.Semantic proximity Read ↗

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