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Article

Suppression of Ras transformation by serum response factor.

The Journal of biological chemistry - 13 May 1994

Kim J H, Johansen F E, Robertson N, Catino J J, Prywes R, Kumar C C

Abstract excerpt

Serum response factor (SRF) is a nuclear transcription factor that binds to the serum response element (SRE) found in the promoter regions of a number of growth factor-inducible genes, as well as muscle-specific genes. The smooth muscle alpha-actin promoter contains two SRE sequences that can bind to SRF. Its expression is repressed in Ras-transformed fibroblast cells and derepressed in revertant cells. In this...

Topics

Actins
Animals
Cell Line, Transformed
Cell Transformation, Neoplastic
Cells, Cultured
DNA-Binding Proteins
Genes, ras
Mice
Mice, Nude
Mutation
Nuclear Proteins
Promoter Regions, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Serum Response Factor

Transcription Factors

Source

Identifiers

PMID: 8188648

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8188648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Suppression of Ras transformation by serum response factor.PMID 8188648Read ↗

Nuclear factor of activated T cells and serum response factor cooperatively regulate the activity of an alpha-actin intronic enhancer.Semantic proximity Read ↗

Transformation blocks differentiation-induced inhibition of serum response factor interactions with serum response elements.Semantic proximity Read ↗

RhoA effector mutants reveal distinct effector pathways for cytoskeletal reorganization, SRF activation and transformation.Semantic proximity Read ↗

Myocardin is a master regulator of smooth muscle gene expression.Semantic proximity Read ↗

Myocardin: a component of a molecular switch for smooth muscle differentiation.Semantic proximity Read ↗

Activation of skeletal alpha-actin gene transcription: the cooperative formation of serum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells.Semantic proximity Read ↗

The induction of smooth muscle alpha actin in a transformed rat cell line suppresses malignant properties in vitro and in vivo.Semantic proximity Read ↗

Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression.Semantic proximity Read ↗

Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression.Semantic proximity Read ↗

Suppression of ras oncogene-mediated transformation.Semantic proximity Read ↗

Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.Semantic proximity Read ↗

Transforming growth factor-beta induction of smooth muscle cell phenotpye requires transcriptional and post-transcriptional control of serum response factor.Semantic proximity Read ↗

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