Article
Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor.
The Journal of biological chemistry - 26 Oct 2001
Zhang X, Chai J, Azhar G, Sheridan P, Borras A M, Furr M C, Khrapko K, Lawitts J, Misra R P, Wei J Y
Abstract excerpt
Serum response factor (SRF) is a key regulator of a number of extracellular signal-regulated genes important for cell growth and differentiation. A form of the SRF gene with a double mutation (dmSRF) was generated. This mutation reduced the binding activity of SRF protein to the serum response element and reduced the capability of SRF to activate the atrial natriuretic factor promoter that contains the serum...
Topics
- Age of Onset
- Animals
- Cardiomyopathy, Dilated
- Female
- Heart
- Male
- Mice
- Mice, Transgenic
- Muscle Proteins
- Mutation
- Myocardium