The inner core of the serum response element mediates both the rapid induction and subsequent repression of c-fos transcription following serum stimulation.

Abstract excerpt

Serum stimulation of quiescent fibroblasts results in a dramatic increase in c-fos transcription that peaks by 15 min and is then rapidly repressed to basal levels within 60 min. Using a nuclear run-on assay to follow directly the kinetics of transcription of mutant c-fos constructs, we demonstrate that the serum response element (SRE) is the site of regulation of both the induction and repression events. This is...

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