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Article

Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.

The Journal of biological chemistry - 10 Mar 2006

Balza Robert O, Misra Ravi P

Abstract excerpt

The serum response factor (SRF) is a transcriptional regulator required for mesodermal development, including heart formation and function. Previous studies have described the role of SRF in controlling expression of structural genes involved in conferring the myogenic phenotype. Recent studies by us and others have demonstrated embryonic lethal cardiovascular phenotypes in SRF-null animals, but have not directly...

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Source

Identifiers

PMID: 16368687
DOI: 10.1074/jbc.M509487200

Genes

SRF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.PMID 16368687Read ↗

Restricted inactivation of serum response factor to the cardiovascular system.Semantic proximity Read ↗

Mosaic inactivation of the serum response factor gene in the myocardium induces focal lesions and heart failure.Semantic proximity Read ↗

SRF: a seriously responsible factor in cardiac development and diseaseSemantic proximity Read ↗

Myocardin Induces Cardiomyocyte HypertrophySemantic proximity Read ↗

Myocardin is a master regulator of smooth muscle gene expression.Semantic proximity Read ↗

SRF-dependent gene expression in isolated cardiomyocytes: Regulation of genes involved in cardiac hypertrophySemantic proximity Read ↗

Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activitySemantic proximity Read ↗

Early postnatal cardiac changes and premature death in transgenic mice overexpressing a mutant form of serum response factor.Semantic proximity Read ↗

Myocardin is sufficient and necessary for cardiac gene expression in Xenopus.Semantic proximity Read ↗

Serum response factor orchestrates nascent sarcomerogenesis and silences the biomineralization gene program in the heart.Semantic proximity Read ↗

Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factorSemantic proximity Read ↗

The serum response factor coactivator myocardin is required for vascular smooth muscle development.Semantic proximity Read ↗

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