Article
Role of the serum response factor in regulating contractile apparatus gene expression and sarcomeric integrity in cardiomyocytes.
The Journal of biological chemistry - 10 Mar 2006
Balza Robert O, Misra Ravi P
Abstract excerpt
The serum response factor (SRF) is a transcriptional regulator required for mesodermal development, including heart formation and function. Previous studies have described the role of SRF in controlling expression of structural genes involved in conferring the myogenic phenotype. Recent studies by us and others have demonstrated embryonic lethal cardiovascular phenotypes in SRF-null animals, but have not directly...
Topics
- Animals
- Animals, Newborn
- Gene Expression Regulation
- Male
- Mice
- Mice, Knockout
- Mutation
- Myocardial Contraction
- Myocytes, Cardiac
- Oligonucleotide Array Sequence Analysis
- Reverse Transcriptase Polymerase Chain Reaction
- Sarcomeres
- Sequence Deletion
- Serum Response Factor