Article
Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators.
Molecular and cellular biology - 1 Oct 2000
Belaguli N S, Sepulveda J L, Nigam V, Charron F, Nemer M, Schwartz R J
Abstract excerpt
Combinatorial interaction among cardiac tissue-restricted enriched transcription factors may facilitate the expression of cardiac tissue-restricted genes. Here we show that the MADS box factor serum response factor (SRF) cooperates with the zinc finger protein GATA-4 to synergistically activate numerous myogenic and nonmyogenic serum response element (SRE)-dependent promoters in CV1 fibroblasts. In the absence of...
Topics
- Actins
- Animals
- Cell Line
- DNA-Binding Proteins
- GATA4 Transcription Factor
- GATA5 Transcription Factor
- GATA6 Transcription Factor
- Gene Expression Regulation
- Genes, Reporter
- Haplorhini
- Muscle, Skeletal