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Article

Reversible inactivation of the transcriptional function of P53 protein by farnesylation.

BMC biotechnology - 29 May 2006

Couderc Bettina, Penary Marie, Tohfe Mustapha, Pradines Anne, Casteignau Antoine, Berg Danièle, Favre Gilles

Abstract excerpt

BACKGROUND: The use of integrating viral vectors in Gene therapy clinical trials has pointed out the problem of the deleterous effect of the integration of the ectopic gene to the cellular genome and the safety of this strategy. We proposed here a way to induce the death of gene modified cells upon request by acting on a pro-apoptotic protein cellular localization and on the activation of its apoptotic function....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16732889
DOI: 10.1186/1472-6750-6-26
PMCID: PMC1481662

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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